潍坊市人民医院 | 潍坊市人民医院主办的英文版杂志《Journal of Aging and Rehabilitation》正式出版

由潍坊市人民医院主办的英文版老年与康复类学术期刊《Journal of Aging and Rehabilitation》创刊号于2024年4月正式出版。

创刊号（第一卷第一期）主要内容为：

开启老龄化和康复研究（社论）

急性脑梗死机械血栓切除术后动脉再闭塞的外科干预进展（综述）

人工智能技术与帕金森病的进展（综述）

儿童脑积水后颅窝肿瘤的诱发因素、手术治疗和预测因素（原创）

依达拉奉右莰醇治疗急性缺血性卒中的有效性和安全性（EXPAND）：一项前瞻性、多中心、真实世界队列研究（原创）

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刊物简介

聚焦老年学、衰老生物学和与年龄相关疾病的病理生理学研究领域最先进理论和技术实践，为老龄化社会和康复服务领域提供国际最前沿的理论和实践支持。期刊欢迎针对影响老年人口的各种疾病的创新疗法和康复方法的研究，包括对动物模型和人体组织或细胞的研究，优先发布临床医生、康复医生和卫生政策制定者直接感兴趣的理论文章，核心目标是通过寻找有针对性的康复治疗方案和方法来提高人们的生活质量。

栏目设置

原创研究论文，高质量的综述，评论和简讯

研究领域

老年病学、衰老生物学和与年龄相关疾病的病理生理学，对各种年龄相关疾病的新疗法和康复方法的研究，包括从动物模型到人体组织和细胞研究的研究。

主编

曾现伟（民政部国家康复辅具研究中心附属康复医院副院长，教授）

苏茂泉（潍坊市人民医院党委书记，研究员）

Huiliang Li, Professor, University College London

主办单位

潍坊市人民医院

Journal of Aging and Rehabilitation

国际同行评审

快审、快发表

开放获取 (Open Access)

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投稿链接

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JAREditorial@vip.163.com

作者面对面

王晓强教授（上海交通大学附属新华医院）

脑积水是神经外科的一种常见疾病，感染、畸形等多种病因可诱发脑积水，脑积水的日常管理占儿科神经外科医生工作量的近一半。脑积水儿童中枢神经系统（CNS）肿瘤的流行病学分布与成人不同。儿童后颅窝肿瘤（PFT）的比例很高，脑积水通常是第一表现，有些病例在手术后出现新发或加重的脑积水。关注脑积水，关注儿童后颅窝肿瘤非常具有现实意义。

我们的文章综述了文献的最新进展和临床实践中遇到的实际问题。对大多数儿童来说，手术引流是最有效的治疗方法；然而，可以在手术或做出明确诊断之前进行药物治疗。PFT是儿童中枢神经系统肿瘤的常见部位，其临床表现常与脑积水有关。在PFT患儿中，可以根据患儿的病情初步预测脑积水的风险，早期预测脑积水风险对治疗方法的选择和相关预后的评估具有明确的临床意义。

马高亭教授（首都医科大学宣武医院）

依达拉奉右莰醇由依达拉奉和右莰醇构成，是一种新型神经保护剂，虽然依达拉奉-右莰醇的疗效已通过先前的随机对照试验（RCT）确定，但缺乏在现实世界实践环境中治疗有效性和安全性的证据。

先前的临床试验主要集中在AIS的早期（症状出现后48小时内）和未接受再灌注治疗的患者，这与临床实践不同。先前临床试验的样本量相对较小，在随机对照试验和真实世界人群之间，具有脆弱特征的个体的代表性极为缺乏。

因此，EXPAND旨在确认依达拉奉右莰醇在现实世界中AIS患者中的作用。EXPAND是全球首个真实世界中探索依达拉奉右莰醇治疗急性脑梗死安全性和有效性的研究，这项研究将阐明依达拉奉右莰醇在真实世界实践中对AIS患者症状出现后14天内的有效性和安全性，我们的研究样本量大，与以前的随机对照试验相比，入组标准要宽松，这使得延长神经保护治疗的治疗时间窗口成为可能，并提出了针对AIS的多靶点研究方案。

Editorial

Opening a new era in aging and rehabilitation research

Xianwei Zeng, Maoquan Su, and Huiliang Li

Journal of Aging and Rehabilitation,1(2024):1-3

DOI:http://dx.doi.org/10.1097/jagr.0000000000000002

The global population is increasingly aging, a trend most prominent in societies characterized by high life expectancy and low fertility rates. The imminent steep rise in the elderly population is set to significantly increase the demand for specialized services. The Journal of Aging and Rehabilitation (JAR), based in China with a global outreach, specializes in the fields of aging and rehabilitation. This professional journal is committed to publishing a diverse array of scholarly content, including original research, review articles, and editorials, all centered around geriatrics and rehabilitation medicine. JAR’s mission extends beyond traditional research dissemination. We are building a vibrant, inclusive community, uniting global voices to shape the future of health care in aging and rehabilitation.

Review Articles

The progression of surgical intervention for arterial reocclusion after mechanical thrombectomy for acute cerebral infarction

Zhigang Jia, Zhicheng Pang, Nan Yang, and Qing Huang

Journal of Aging and Rehabilitation,1(2024):4-12

DOI:http://dx.doi.org/10.1097/jagr.0000000000000005

Acute ischemic stroke, a prevalent cerebrovascular disease, significantly contributes to mortality and morbidity in modern society. Although early mechanical thrombectomy is beneficial for many patients, a subset still suffers from failed recanalization due to arterial occlusion (AR) post-thrombectomy, owing to a variety of factors. Therefore, minimizing vascular reocclusion rates is imperative in improving outcomes for patients with acute cerebral infarction. Recent surgical intervention studies have concentrated on vascular recanalization after mechanical thrombectomy. This review critically analyzes the pathophysiology and effective treatments for vascular reocclusion, providing insight into the latest developments and outlining challenges for future research.

The progression of artificial intelligence technology and Parkinson’s disease

Xianyue Meng, Anqi Huang, and Xueli Li

Journal of Aging and Rehabilitation,1(2024):13-16

DOI:http://dx.doi.org/10.1097/jagr.0000000000000004

Parkinson’s disease is a neurodegenerative disease that seriously endangers the health of middle-aged and old people and is characterized by the degeneration of nigrostriatal dopaminergic neurons as its main pathologic feature. Due to its numerous influencing factors, unclear pathogenic mechanisms, and complex clinical manifestations, the diagnosis and treatment of Parkinson’s disease still face huge challenges. In recent years, artificial intelligence technology has developed rapidly and its application in the medical field has become increasingly widespread. This article reviews the achievements of artificial intelligence in the diagnosis and treatment of Parkinson’s disease, with a view to benefiting patients with Parkinson’s disease in the future.

Original Research

Influencing factors, surgical management, and predictors of posterior fossa tumors with hydrocephalus in children

Jiaqi Feng, Tianyi Zhang, Dake He, Weiwei Mao, Weiping Wang, Yabing Zhou, and Xiaoqiang Wang

Journal of Aging and Rehabilitation,1(2024):17-21

DOI:http://dx.doi.org/10.1097/jagr.0000000000000003

Hydrocephalus is a common disease in neurosurgery, and its daily management accounts for nearly half of the workload of pediatric neurosurgeons. The epidemiological distribution of pediatric central nervous system (CNS) tumors differs from that of adults. The proportion of posterior fossa tumors (PFTs) in children is high, hydrocephalus is often the first manifestation, and some cases have denovo or aggravated hydrocephalus after surgery. However, controversies remain regarding the best treatment methods and timelines for PFT with hydrocephalus. This article reviews the latest progress in the literature and practical problems encountered in clinical practices.

Effectiveness and safety of edaravone dexborneol in acute ischemic stroke (EXPAND): Study protocol for a prospective, multicenter, real-world cohort study

Gaoting Ma, Ran Mo, Shaoyuan Lei, Xiaoxi Yao, Zhiwei Song, Weizheng Xie, Guangxiong Yuan, Jin Hu, Yutie Zhao, Dongsheng Ju, Xiafeng Yang, Shudong Cao, Jintao Guo, Xiaodong Liu, Chunsheng Cai, Jianhua Li, Yifan Wu, Yingting Zuo, Shujuan Meng, Yue Wu, Ziying Jiang, Qian Zhang, Yi Ren, Qingfeng Ma, Pingping Wang, Lianmei Zhong, Yansu Guo, Haiqing Song, and on behalf of the EXPAND investigators

Journal of Aging and Rehabilitation,1(2024):22-27

DOI:http://dx.doi.org/10.1097/jagr.0000000000000001

Edaravone dexborneol has been confirmed as a novel neuroprotective agent by acting on multiple active targets of antioxidation and anti-inflammation. This study aims to evaluate the effectiveness and safety of edaravone dexborneol in patients with acute ischemic stroke (AIS) within 14 days of symptom onset in real-world clinical practice.

供稿 │ 科研管理部 王少强